Review



except ibtx  (Biosynth Carbosynth)


Bioz Verified Symbol Biosynth Carbosynth is a verified supplier
Bioz Manufacturer Symbol Biosynth Carbosynth manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    Biosynth Carbosynth except ibtx
    EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with <t>IBTX.</t> This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 <t>IBTX</t> and hypoxia inhibit IK, respectively).
    Except Ibtx, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 90/100, based on 38 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/pmc00022167-190-5-7?v=Biosynth+Carbosynth
    Average 90 stars, based on 38 article reviews
    except ibtx - by Bioz Stars, 2026-08
    90/100 stars

    Images

    1) Product Images from "O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase"

    Article Title: O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase

    Journal:

    doi:

    EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with IBTX. This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 IBTX and hypoxia inhibit IK, respectively).
    Figure Legend Snippet: EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with IBTX. This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 IBTX and hypoxia inhibit IK, respectively).

    Techniques Used:



    Similar Products

    hellobio except iberiotoxin  (Alomone Labs)
    95
    Alomone Labs hellobio except iberiotoxin
    Hellobio Except Iberiotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/pm36750122-38-5-8?v=Alomone+Labs
    Average 95 stars, based on 1 article reviews
    hellobio except iberiotoxin - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    sigmaaldrich except iberiotoxin  (Alomone Labs)
    95
    Alomone Labs sigmaaldrich except iberiotoxin
    FIG. 5. Relative volume measurements in response to 4-PDD in cystic fibrosis airway epithelial cells. A, cell volume changes in CFT1 cells exposed to hypotonic conditions in the absence (, n 12) or presence of 1 M 4-PDD (●, n 13). B, cell volume changes in CFT1 cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 12) or in the presence of 100 mM Gd3 (‚, n 9). C, cell volume changes in CFT1 cells exposed to 1 M 4-PDD and 100 nM clotrimazole (n 12). D, cell volume changes in CFBE cells exposed to 1 M 4-PDD (n 9). E, cell volume changes in CFBE cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 10) or in the presence of 100 mM Gd3 (‚, n 6). F, cell volume changes in CFBE cells exposed to 1 M 4-PDD and 100 nM <t>iberiotoxin</t> (n 7).
    Sigmaaldrich Except Iberiotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/10__1074_slash_jbc__m409708200-61-5-8?v=Alomone+Labs
    Average 95 stars, based on 1 article reviews
    sigmaaldrich except iberiotoxin - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    except iberiotoxin  (Alomone Labs)
    95
    Alomone Labs except iberiotoxin
    FIG. 5. Relative volume measurements in response to 4-PDD in cystic fibrosis airway epithelial cells. A, cell volume changes in CFT1 cells exposed to hypotonic conditions in the absence (, n 12) or presence of 1 M 4-PDD (●, n 13). B, cell volume changes in CFT1 cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 12) or in the presence of 100 mM Gd3 (‚, n 9). C, cell volume changes in CFT1 cells exposed to 1 M 4-PDD and 100 nM clotrimazole (n 12). D, cell volume changes in CFBE cells exposed to 1 M 4-PDD (n 9). E, cell volume changes in CFBE cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 10) or in the presence of 100 mM Gd3 (‚, n 6). F, cell volume changes in CFBE cells exposed to 1 M 4-PDD and 100 nM <t>iberiotoxin</t> (n 7).
    Except Iberiotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/10__1074_slash_jbc__m409708200-61-6-8?v=Alomone+Labs
    Average 95 stars, based on 1 article reviews
    except iberiotoxin - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    sigma aldrich except iberiotoxin  (Alomone Labs)
    95
    Alomone Labs sigma aldrich except iberiotoxin
    FIG. 5. Relative volume measurements in response to 4-PDD in cystic fibrosis airway epithelial cells. A, cell volume changes in CFT1 cells exposed to hypotonic conditions in the absence (, n 12) or presence of 1 M 4-PDD (●, n 13). B, cell volume changes in CFT1 cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 12) or in the presence of 100 mM Gd3 (‚, n 9). C, cell volume changes in CFT1 cells exposed to 1 M 4-PDD and 100 nM clotrimazole (n 12). D, cell volume changes in CFBE cells exposed to 1 M 4-PDD (n 9). E, cell volume changes in CFBE cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 10) or in the presence of 100 mM Gd3 (‚, n 6). F, cell volume changes in CFBE cells exposed to 1 M 4-PDD and 100 nM <t>iberiotoxin</t> (n 7).
    Sigma Aldrich Except Iberiotoxin, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/pm12388065-44-6-9?v=Alomone+Labs
    Average 95 stars, based on 1 article reviews
    sigma aldrich except iberiotoxin - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    except ibtx  (Biosynth Carbosynth)
    90
    Biosynth Carbosynth except ibtx
    EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with <t>IBTX.</t> This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 <t>IBTX</t> and hypoxia inhibit IK, respectively).
    Except Ibtx, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/except+ibtx/pmc00022167-190-5-7?v=Biosynth+Carbosynth
    Average 90 stars, based on 1 article reviews
    except ibtx - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    FIG. 5. Relative volume measurements in response to 4-PDD in cystic fibrosis airway epithelial cells. A, cell volume changes in CFT1 cells exposed to hypotonic conditions in the absence (, n 12) or presence of 1 M 4-PDD (●, n 13). B, cell volume changes in CFT1 cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 12) or in the presence of 100 mM Gd3 (‚, n 9). C, cell volume changes in CFT1 cells exposed to 1 M 4-PDD and 100 nM clotrimazole (n 12). D, cell volume changes in CFBE cells exposed to 1 M 4-PDD (n 9). E, cell volume changes in CFBE cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 10) or in the presence of 100 mM Gd3 (‚, n 6). F, cell volume changes in CFBE cells exposed to 1 M 4-PDD and 100 nM iberiotoxin (n 7).

    Journal: Journal of Biological Chemistry

    Article Title: Swelling-activated Ca2+ Entry via TRPV4 Channel Is Defective in Cystic Fibrosis Airway Epithelia

    doi: 10.1074/jbc.m409708200

    Figure Lengend Snippet: FIG. 5. Relative volume measurements in response to 4-PDD in cystic fibrosis airway epithelial cells. A, cell volume changes in CFT1 cells exposed to hypotonic conditions in the absence (, n 12) or presence of 1 M 4-PDD (●, n 13). B, cell volume changes in CFT1 cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 12) or in the presence of 100 mM Gd3 (‚, n 9). C, cell volume changes in CFT1 cells exposed to 1 M 4-PDD and 100 nM clotrimazole (n 12). D, cell volume changes in CFBE cells exposed to 1 M 4-PDD (n 9). E, cell volume changes in CFBE cells exposed to hypotonic solutions containing 1 M 4-PDD in the absence of extracellular Ca2 (●, n 10) or in the presence of 100 mM Gd3 (‚, n 6). F, cell volume changes in CFBE cells exposed to 1 M 4-PDD and 100 nM iberiotoxin (n 7).

    Article Snippet: All chemicals were purchased from SigmaAldrich except iberiotoxin (Alomone Laboratories, Jerusalem, Israel).

    Techniques:

    EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with IBTX. This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 IBTX and hypoxia inhibit IK, respectively).

    Journal:

    Article Title: O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase

    doi:

    Figure Lengend Snippet: EM and IK are similar in resistance PASMCs from wild-type and CGD mice (A) Resting EM is similar in wild-type (filled bar) and CGD (empty bar) PASMCs. (B) Normoxic current density is similar in wild-type and CGD PASMCs. (C and D) In PASMCs from CGD mice, 4-AP, a Kv channel inhibitor, reduces IK at negative potentials (−10 mV, C, ∗, P < 0.05). Tetraethylammonium (TEA) inhibits IK only at positive potentials, where KCa channels are active (∗, P < 0.05, D). (E and F) Four minutes of acute hypoxia inhibits IK (n = 4 cells/group, ∗, P < 0.01). (G and H) In separate experiments, 4 min of acute hypoxia inhibits IK even after specifically inhibiting large conductance KCa channels with IBTX. This finding suggests the hypoxia-sensitive current is at least partially Kv current (†, ∗ P < 0.05 IBTX and hypoxia inhibit IK, respectively).

    Article Snippet: All drugs were from Sigma except IBTX (Peptides International) and DPI (Research Biochemicals, Natick, MA).

    Techniques: